neurofilament light chain as a biomarker in neurological disorders

. Keywords: The objective of this study was to investigate the serum neurofilament light chain (NfL) as a novel biomarker of neurological dysfunction in MELAS. This reference is a comprehensive work in the field of neurotrauma and critical care. It incorporates the fields of head injury, spinal injury and basic neurotrauma research into one source. 2019-07-03T10:37:44+01:00 Plasma Total-Tau and Neurofilament Light Chain as Diagnostic Biomarkers of Alzheimer's Disease Dementia and Mild Cognitive Impairment in Adults with Down Syndrome. Plasma Concentration of the Neurofilament Light Protein (NFL) is a Biomarker of CNS Injury in HIV Infection: A Cross-Sectional Study. MeSH Disanto G, Barro C, Benkert P, Naegelin Y, Schädelin S, et al; Swiss Multiple Sclerosis Cohort Study Group. Please enable it to take advantage of the complete set of features! Neurofilaments as biomarkers in neurological disorders. 10.1007/s12035-019-01698-3 [Epub ahead of print]. Combination of serum and CSF neurofilament-light and neuroinflammatory biomarkers to evaluate ALS. 575 0 obj 2021-10-01T07:50:27-07:00 727ac6ce-055f-48f1-96ea-34513398852e Gaetani L, Blennow K, Calabresi P, et al. 8. NfL is an integral component of axons and is released into the bloodstream and cerebrospinal fluid during neurodegeneration; hence it can be used to monitor disease progression. Neurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons. <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>> An increase of NfL levels in the CSF and blood reflects the degree of axonal damage in neurological diseases of dif-ferent etiologies, including inflammatory, trau- Phosphorylated neurofilament heavy subunit (pNF-H) in peripheral blood and CSF as a potential prognostic biomarker in amyotrophic lateral sclerosis. Disclaimer, National Library of Medicine CSF neurofilament proteins as diagnostic and prognostic biomarkers for amyotrophic lateral sclerosis. 162 0 obj In infants with spinal muscular atrophy (SMA) type 1, lower blood levels of phosphorylated neurofilament heavy chain (pNF-H) — a marker of nerve cell damage — before starting treatment with Spinraza (nusinersen) are significantly associated with greater motor gains over time. The aim of this study was to investigate the biomarker potential of blood NfL concentrations in patients with A-T. The value of neurofilament light chain (NfL) as a prognostic blood biomarker in various neurological diseases has been highlighted by three recently published studies. 342 0 obj J Neurol Neurosurg Psychiatry . <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>> 2021 Sep 22. doi: 10.1007/s12035-021-02562-z. In particular, neurofilament light chain protein (NfL) is a dynamic marker of active neuronal damage. Neurofilament light chain (NfL) is a neuron-specific cytoskeletal protein expressed in axons. The Simple Plex neurofilament light assay can quantify this biomarker in serum and plasma samples to provide highly robust and reproducible data. eCollection 2016 Jan. Wang SY, Chen W, Xu W, Li JQ, Hou XH, Ou YN, Yu JT, Tan L. J Alzheimers Dis. 2019 Aug;90(8):870-881. doi: 10.1136/jnnp-2018-320106. What was once possible only with spinal fluid now looks to be reproducible in blood. Spicer C, Lu CH, Catapano F, Scoto M, Zaharieva I, Malaspina A, Morgan JE, Greensmith L, Muntoni F, Zhou H. Ann Clin Transl Neurol. A few previous studies in small co-horts of GBS patients have demonstrated prognostic properties for neurofilament heavy chain (NfH) and light Hence, neurofilaments are now increasingly recognized as the most promising candidate biomarker in amyotrophic lateral sclerosis. Abnormal assembly of neurofilaments is found in several human neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), infantile spinal muscular atrophy (SMA), and hereditary sensory-motor neuropathy (HSMN). Prevention and treatment information (HHS). Neurofilament light chain (NfL) is a marker of brain atrophy and predictor of disease progression in rare diseases such as Huntington Disease, but also in more common neurological disorders such as Alzheimer's disease. Among biomarkers able to detect neurological diseases already in their preclinical phase, neurofilament light chain (NfL) has given the most promising results. 4 . Background: Parkinson disease (PD) is a common neurodegenerative disorder. Different types of Nfs could be released in the CSF, serum and plasma. endstream 1998;61:1-23. doi: 10.1016/s0079-6603(08)60823-5. Found inside"This authoritative work, now thoroughly revised, has given thousands of clinicians, students, and researchers a state-of-the-art understanding of the human frontal lobes--the large brain region that plays a critical role in behavior, ... endobj The work shows that blood . 2018 Mar;265(3):510-521. doi: 10.1007/s00415-017-8730-6. [ PubMed ] [ Google Scholar ] Prevention and treatment information (HHS). Injured motor neurons in the spinal cord and brain are ALS pathogenesis characteristic. 670 0 obj eCollection 2020. We aimed to investigate if serum NfL (sNfL) levels can be a biomarker of disease activity and treatment response in patients with chronic inflammatory . 6, 7 Glial fibrillary acidic protein (GFAp), highly expressed in astrocytes, is a biomarker of . Rev. Its levels increase in cerebrospinal fluid (CSF) and blood proportionally to the degree of axonal damage in a variety of neurological disorders, including inflammatory, neurodegenerative, traumatic and cerebrovascular diseases. Gaetani L, Blennow K, Calabresi P, Di Filippo M, Parnetti L, Zetterberg H. Neurofilament light chain as a biomarker in neurological disorders. DOI: 10.1136/jnnp-2018-320106 Corpus ID: 106408048. The search for diagnostic and prognostic biomarkers for neurodegenerative conditions is of high importance, since these disorders may present difficulties in differential diagnosis. Neurofilament light chain (NfL) levels have been suggested as reflecting axonal damage in various inflammatory and neurodegenerative disorders, including acquired peripheral neuropathies. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 revealed neurological disorders to be the leading cause of disability and the second cause of death after cardiovascular diseases [].Neurological disorders - particularly central nervous system (CNS) disorders - have suffered from a relative lack of biomarkers for screening, diagnosis and/or follow-up. Background: Damage to axonal cells releases neurofilament light chain (NFL) into the cerebrospinal fluid and plasma. Gaetani L, Blennow K, Calabresi P, Di Filippo M, Parnetti L, Zetterberg H. Neurofilament light chain as a biomarker in neurological disorders. 8600 Rockville Pike Figure 1.. A schematic of different types…, Figure 1.. A schematic of different types of Nfs and their detection in CNS related…, A schematic representation of normal and ALS nerve cell. Throughout, a practical approach is adopted, geared specifically to the needs of clinicians (neurologists, radiologists, psychiatrists, geriatricians) working in the field of dementia, for whom this book should prove an invaluable resource. Mol. <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>> An alteration…. PMC Its levels increase in cerebrospinal fluid (CSF) and blood proportionally to the degree of axonal damage in a variety of neurological disorders, including inflammatory, neurodegenerative, traumatic and cerebrovascular diseases. <>stream 10 Feb 2017. . ADS CAS Article Google Scholar uuid:a503b81a-1dd1-11b2-0a00-9000b865e5ff MRIs were graded according to enhancing lesions at different central nervous system (CNS) sites. Gaetani L, Blennow K, Calabresi P, Di Filippo M, Parnetti L, et al. Higher blood levels of neurofilament light chain (sNfL) were linked with disability, brain atrophy, and other features of multiple sclerosis (MS) in an ongoing and real-world study, reinforcing . False Many studies have investigated NfL in both CSF and serum/plasma as a potential biomarker of neurodegenerative disorders. Gisslén M, Price RW, Andreasson U, Norgren N, Nilsson S, Hagberg L, Fuchs D, Spudich S, Blennow K, Zetterberg H. EBioMedicine. Found insideReports on recent advances in detecting drugs, hormones, antibodies, and other molecules of diagnostic importance; research has been going on in such fields as dentistry, clinical chemistry, and steroid hormones, but the researchers have ... Over the past five years ongoing research has greatly expanded our understanding of the pathogenesis of MS, detailed insight into the epidemiology and genetic factors related to MS, the introduction of new technologies and tests to better ... Neurofilament light chain (NfL) is a unique biomarker related to axonal damage and neural cell death, which is elevated in a number of neurological disorders, and can be detected in cerebrospinal fluid (CSF), as well as blood, serum, or plasma samples. endobj Fang X, Liang Y, Zhang W, Wang Q, Chen J, Chen J, Lin Y, Chen Y, Yu L, Wang H, Chen D. Mol Neurobiol. Front Aging Neurosci. Clipboard, Search History, and several other advanced features are temporarily unavailable. This book comprehensively reviews the current state of clinical trial methods in multiple sclerosis treatment, providing investigators, sponsors and specialists with current knowledge of outcome measures and study designs for disease and ... New quantitative analyses and assay techniques are well-developed for the detection of neurofilament proteins, particularly NF-L and the phosphorylated NF-H (pNF-H) in CSF and serum. 3 Unlike total tau and NfL levels that increase in different brain disorders, the plasma level of tau protein phosphorylated at threonine residue 181 (pTau181) is relatively specific and predictive of AD. These findings, based on data from the Phase 3 ENDEAR trial and the SHINE extension study, contrast with those . <> The aim of the proposal is to measure and evaluate neurofilament-light chain as serum biomarker of disease progression in A-T patients. 577 0 obj Neurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons. endobj Found insideThis book summarizes what is known about the etiology, pathogenesis, natural history, and clinical features of neurocognitive disturbance in HIV infection. Karoly HC, Skrzynski CJ, Moe E, Bryan AD, Hutchison KE. Front Neurosci. Gagliardi D, Meneri M, Saccomanno D, Bresolin N, Comi GP, Corti S. Int J Mol Sci. Neurofilament light chain (NfL) is an emerging biomarker of neural degeneration. Found inside – Page iiiThis manual takes a multidisciplinary approach to neurological disorders in the elderly. New quantitative analyses and assay techniques are well-developed for the detection of neurofilament proteins, particularly NF-L and the phosphorylated NF-H (pNF-H) in CSF . 576 0 obj Neurofilament Light. 155 0 obj biomarker research in a variety of neurological disorders [14-17]. 2016 Jan;79(1):152-8. doi: 10.1002/ana.24552. Additionally, the investigators will measure neurofilament-light chain in CSF from their human biobank and characterize the individual evolution in the serum of whole blood taken from the biobank. Objective . Plasma Neurofilament Light Validated Biomarker for Neurological Conditions. Objectives To determine whether plasma and CSF NfL (1) associate with motor or cognitive status in Parkinson's disease (PD) and (2) predict future motor or cognitive decline in PD. Comprehensive and cutting-edge, The Handbook of Biomarkers serves as a vital guide to furthering our understanding of biomarkers, which, by facilitating the combination of therapeutics with diagnostics, promise to play an important role in ... <>stream Found insideThe Behavioral Neurology of Dementia is a comprehensive textbook that offers a unique and modern approach to the diagnosis and treatment of patients with dementing conditions in the twenty-first century. Despite the great progress made in the past decade, VaD still lacks effective treatments and peripheral blood biomarkers. Found insideThis book covers essential aspects of cerebrospinal fluid analysis and its use in the diagnosis of common neurological diseases. Increased neurofilament light chain (NfL) levels have been found in the blood and cerebrospinal fluid (CSF) in several neurological disorders, including MS.
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